Description

Benzene, 1-Bromo-4-(Pentafluoroethoxy)- is a specialized fluorinated aromatic building block, identified by CAS No. 56425-85-5. This compound is valued for its unique molecular architecture, combining a bromo substituent with a highly electron-withdrawing pentafluoroethoxy group, making it a critical intermediate for advanced synthesis. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical sectors for constructing complex molecules where fluorine incorporation is desired to modulate biological activity, metabolic stability, and physicochemical properties.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing fluorinated aryl ether motifs.
• Agrochemical Synthesis: Used in developing novel herbicides, fungicides, and insecticides where the pentafluoroethoxy group enhances lipophilicity and target binding.
• Material Science Research: Employed in the creation of specialty polymers, liquid crystals, and organic electronic materials due to its ability to influence electronic properties.
• Cross-Coupling Reactions: Acts as a competent substrate in palladium-catalyzed reactions (e.g., Suzuki, Sonogashira) where the bromine serves as a handle for further functionalization.
• Fluorine Chemistry Studies: A valuable reagent for investigating structure-activity relationships (SAR) and the effects of polyfluorinated alkoxy groups.

Basic Information

Product Name	Benzene, 1-Bromo-4-(Pentafluoroethoxy)-
CAS No.	56425-85-5
Molecular Formula	C8H4BrF5O
Molecular Weight	291.02 g/mol
Synonyms	1-Bromo-4-(pentafluoroethoxy)benzene; 4-Bromophenyl pentafluoroethyl ether; p-Bromo(pentafluoroethoxy)benzene; Benzene, 1-bromo-4-(pentafluoroethoxy)-; 4-Bromo-1-(pentafluoroethoxy)benzene; Pentafluoroethoxy-4-bromobenzene; (4-Bromophenoxy)pentafluoroethane
EINECS	Contact for details

Quality Control

Every batch of Benzene, 1-Bromo-4-(Pentafluoroethoxy)- is produced and analyzed under strict quality management protocols. We ensure high-purity standards suitable for demanding research and scale-up applications. Comprehensive analytical testing, including GC, HPLC, NMR, and GC-MS, is performed to verify identity, purity, and impurity profiles. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.