Description

Diethyl 4-(Trifluoromethyl)Tetrafluorophenylmalonate is a high-purity fluorinated malonate ester derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in the unique reactivity of the malonate moiety and the electronic properties imparted by the polyfluorinated aromatic system, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing fluorinated drug candidates, including protease inhibitors and kinase inhibitors, where the trifluoromethyl and tetrafluoroaryl groups enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, leveraging the fluorine atoms to improve lipophilicity and environmental persistence of the active ingredient.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and coatings with enhanced chemical resistance and thermal stability.
• Liquid Crystal & OLED Materials: Acts as a synthetic intermediate for fluorinated components in electronic display materials, contributing to improved dielectric properties and performance.
• Organic Synthesis Reagent: Utilized in palladium-catalyzed cross-coupling reactions, Claisen condensations, and other carbon-carbon bond-forming transformations to introduce complex fluorinated aromatic segments.

Basic Information

Product Name	Diethyl 4-(Trifluoromethyl)Tetrafluorophenylmalonate
CAS No.	55810-48-5
Molecular Formula	C₁₄H₁₁F₇O₄
Molecular Weight	376.23 g/mol
Synonyms	Diethyl (2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)malonate; Diethyl (Perfluorotolyl)malonate; 4-(Trifluoromethyl)tetrafluorophenylmalonic Acid Diethyl Ester; 2,3,5,6-Tetrafluoro-4-(trifluoromethyl)phenylmalonic Acid Diethyl Ester; Pentafluorophenylmalonate Derivative; Ethyl 4-(Trifluoromethyl)Tetrafluorophenylmalonate; CAS 55810-48-5
EINECS	Contact for details

Quality Control

Our production of Diethyl 4-(Trifluoromethyl)Tetrafluorophenylmalonate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR to verify identity and quantify impurities. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and specific impurity profiles is provided with every shipment, supporting your R&D and scale-up activities with reliable data.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. The container should be kept tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.