Description

4-Difluoromethyl-Benzylamine Hydrochloride is a high-purity organic building block of significant importance in advanced chemical synthesis. This compound is valued for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the difluoromethyl group can impart desirable metabolic stability and bioavailability. It is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms can enhance biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of novel polymers and advanced organic materials with specific electronic or structural properties.
• Chemical Biology Probes: Utilized as a scaffold for developing molecular probes and fluorescent tags for biochemical and diagnostic applications.

Basic Information

Product Name	4-Difluoromethyl-Benzylamine Hydrochloride
CAS No.	55805-28-2
Molecular Formula	C8H9F2N•HCl
Molecular Weight	193.62 g/mol (Free base: 157.16 g/mol)
Synonyms	4-(Difluoromethyl)benzylamine hydrochloride; 1-[4-(Difluoromethyl)phenyl]methanamine hydrochloride; Benzenemethanamine, 4-(difluoromethyl)-, hydrochloride; α-(Difluoromethyl)-p-toluidine hydrochloride; (4-(Difluoromethyl)phenyl)methanamine hydrochloride; p-(Difluoromethyl)benzylamine HCl; 4-Difluoromethylbenzylamine HCl
EINECS	Contact for details

Quality Control

Our 4-Difluoromethyl-Benzylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and Karl Fischer titration, to ensure it meets the high-purity standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.