Description

L-Tyrosine, N,o-Bis(Trimethylsilyl)-3-[(Trimethylsilyl)Oxy]-, Trimethy Lsilyl Ester is a fully silylated derivative of the amino acid L-tyrosine, designed to enhance volatility and thermal stability for advanced analytical and synthetic processes. This compound is critical for researchers and manufacturers requiring precise derivatization to enable gas chromatography (GC) analysis of amino acids or to protect reactive hydroxyl and amine groups during complex organic synthesis. It serves as a key intermediate and analytical standard in pharmaceutical research, proteomics, and the development of high-value specialty chemicals.

Application

• Gas Chromatography (GC) and GC-Mass Spectrometry (GC-MS) Analysis: Used as a derivatization agent to convert L-tyrosine and other polar amino acids into volatile, thermally stable trimethylsilyl (TMS) derivatives for accurate identification and quantification.
• Pharmaceutical Intermediate: Serves as a protected synthon in the multi-step synthesis of complex drug molecules, peptides, and tyrosine-based compounds, where selective deprotection is required.
• Proteomics and Metabolomics Research: Acts as a critical standard or reagent in the analysis of protein hydrolysates, metabolic pathways, and biomarker discovery.
• Reference Standard: Provides a high-purity certified material for method development, validation, and quality control in analytical laboratories.
• Specialty Chemical Synthesis: Utilized in organic synthesis to introduce protected tyrosine moieties into larger molecular architectures, such as ligands, catalysts, or advanced materials.
• Biochemical Research: Employed in studies investigating tyrosine metabolism, neurotransmitter synthesis (dopamine, epinephrine), and enzyme activity.

Basic Information

Product Name	L-Tyrosine, N,o-Bis(Trimethylsilyl)-3-[(Trimethylsilyl)Oxy]-, Trimethy Lsilyl Ester
CAS No.	55638-45-4
Molecular Formula	C21H45NO4Si4
Molecular Weight	519.96 g/mol
Synonyms	L-Tyrosine, N,O,O-tris(trimethylsilyl)-, trimethylsilyl ester; Tris(trimethylsilyl) L-tyrosine trimethylsilyl ester; N,O,O-Tris(trimethylsilyl)-L-tyrosine O-trimethylsilyl ester; L-Tyrosine, tris(trimethylsilyl)-, trimethylsilyl ester; Fully silylated L-tyrosine; TMS-L-Tyrosine; L-Tyrosine TMS derivative; Tyrosine TMS ester
EINECS	Contact for details

Quality Control

Our L-Tyrosine TMS derivative is produced under controlled conditions to ensure high chemical purity and consistency, meeting the stringent requirements of research and analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous internal quality standards and can provide material tailored to specific customer specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions, such as in a glovebox or under an inert atmosphere, to prevent decomposition. Keep away from fluoride sources and strong alkali.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (GC)	≥ 98.0% (TMS derivative)
Optical Rotation	Contact for details
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.