Description

Trimethylsilyl 3-Methylbutyrate is a specialized organosilicon ester, a key reagent and intermediate in advanced organic synthesis. Its primary value lies in its dual functionality, serving as a versatile silylating agent and a protected form of 3-methylbutyric acid, enabling precise chemical transformations. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and fragrance industries, where it facilitates the synthesis of complex molecules and fine chemicals.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) and prodrugs, particularly where silyl protection of carboxylic acid groups is required.
• Agrochemical Synthesis: Serves as a key building block in the production of advanced pesticides, herbicides, and plant growth regulators.
• Flavor and Fragrance Ingredient: Acts as a precursor or protected intermediate in the manufacture of esters and other compounds for high-value aroma chemicals.
• Organic Synthesis Reagent: Employed as a silylating agent to introduce the trimethylsilyl (TMS) group, protecting reactive sites during multi-step synthetic sequences.
• Polymer and Material Science: Utilized in the modification of polymer surfaces and the synthesis of silicon-containing hybrid materials.
• Analytical Chemistry: Can be used as a derivatization agent in gas chromatography (GC) and mass spectrometry (MS) for the analysis of volatile compounds.

Basic Information

Product Name	Trimethylsilyl 3-Methylbutyrate
CAS No.	55557-13-6
Molecular Formula	C8H18O2Si
Molecular Weight	174.31 g/mol
Synonyms	3-Methylbutyric Acid Trimethylsilyl Ester; Isovaleric Acid Trimethylsilyl Ester; Trimethylsilyl Isovalerate; TMS-Isovalerate; (CH3)3SiOCOCH2CH(CH3)2; Trimethyl(3-methylbutanoyloxy)silane; Trimethylsilyl 3-methylbutanoate
EINECS	Contact for details

Quality Control

Our Trimethylsilyl 3-Methylbutyrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and IR spectroscopy, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports applications requiring reliable and reproducible performance in sensitive synthetic processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.410 - 1.415
Density (g/mL at 20°C)	0.85 - 0.87

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.