Description

Benzo-[1,3,2]-Dioxa-Phosphol-2-Yl Isocyanate is a specialized organophosphorus isocyanate compound, serving as a critical building block for introducing reactive isocyanate functionality into complex molecular architectures. Its primary value lies in its dual functionality, combining the reactivity of an isocyanate group with the unique properties of a cyclic phosphite ester, enabling the synthesis of novel polymers, ligands, and pharmaceutical intermediates. This high-purity reagent is essential for R&D and production in advanced material science, agrochemical development, and medicinal chemistry, where precise molecular design is paramount.

Application

• Pharmaceutical Intermediate: A key synthon for constructing novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug research.
• Polymer Modification: Used as a reactive monomer or cross-linking agent to introduce phosphorus-containing groups into polyurethanes, epoxies, and other specialty polymers, enhancing flame retardancy or adhesion properties.
• Agrochemical Synthesis: Employed in the production of advanced herbicides, insecticides, and fungicides that require phosphorus-based bioactive components.
• Ligand Synthesis: Acts as a precursor for creating sophisticated phosphorus-containing ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Surface Functionalization: Used to modify material surfaces (e.g., silica, metals) with isocyanate groups for subsequent coupling with amines or alcohols, creating tailored interfaces.
• Flame Retardant Additive Precursor: Incorporated into the backbone of polymeric flame retardants to improve thermal stability and efficiency.

Basic Information

Product Name	Benzo-[1,3,2]-Dioxa-Phosphol-2-Yl Isocyanate
CAS No.	55550-17-9
Molecular Formula	C8H6NO3P
Molecular Weight	195.11 g/mol
Synonyms	2-Isocyanato-1,3,2-benzodioxaphosphole; 1,3,2-Benzodioxaphosphole, 2-isocyanato-; 2-Isocyanato-2H-1,3,2-benzodioxaphosphole; Benzo-1,3,2-dioxaphosphol-2-yl isocyanate; Phenyl isocyanatophosphate cyclic ester; BDPI; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our production of Benzo-[1,3,2]-Dioxa-Phosphol-2-Yl Isocyanate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analysis, including assay by titration or HPLC, identity confirmation via FT-IR and NMR spectroscopy, and impurity profiling. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at temperatures between 2°C and 8°C (refrigerated) or as specified on the label. Due to its moisture-sensitive (hygroscopic) nature, containers must be kept sealed under an inert atmosphere (argon or nitrogen) after opening to prevent hydrolysis and maintain product integrity. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.4 g/cm³
Refractive Index (n20D)	~1.55

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.