Description

(17S,20S)-17,20-[(tert-Butylboranediyl)Bis(Oxy)]-5β-Pregnan-3α-Ol CAS NO 55521-03-4 is a high-purity, synthetic steroid derivative featuring a unique tert-butylboranediyl bis(oxy) protecting group at the 17,20-positions. This compound is a critical advanced intermediate in the synthesis of complex steroid-based pharmaceuticals and fine chemicals, offering precise stereochemical control for downstream reactions. It is primarily utilized by research institutions and pharmaceutical manufacturers specializing in hormone-related therapies, drug discovery, and the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel steroid-based active pharmaceutical ingredients (APIs) for therapeutic applications.
• Research & Development: Used in medicinal chemistry and process chemistry research for exploring new synthetic pathways and protecting group strategies in steroid chemistry.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Fine Chemical Synthesis: Employed in the production of specialized steroid derivatives for biochemical research and diagnostic applications.
• Process Development: Utilized for scaling up and optimizing synthetic routes in pilot plants and commercial manufacturing settings.

Basic Information

Product Name	(17S,20S)-17,20-[(tert-Butylboranediyl)Bis(Oxy)]-5β-Pregnan-3α-Ol
CAS No.	55521-03-4
Molecular Formula	C₂₉H₅₁BO₃
Molecular Weight	458.53 g/mol
Synonyms	5β-Pregnan-3α-ol, 17,20-[(1,1-dimethylethyl)boranediyl]bis[oxy]-, (17S,20S)-; (17S,20S)-17,20-[(tert-Butylboranediyl)bis(oxy)]-5β-pregnan-3α-ol; 3α-Hydroxy-5β-pregnane-17,20-diyl tert-butyl boronate; Steroid tert-butylboronate intermediate; 17,20-O-(tert-Butylboranediyl)-5β-pregnan-3α-ol; Pregnane boronate derivative.
EINECS	Contact for details

Quality Control

Our (17S,20S)-17,20-[(tert-Butylboranediyl)Bis(Oxy)]-5β-Pregnan-3α-Ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and specific tests for residual solvents and moisture content. We provide full traceability and detailed Certificates of Analysis (COA) to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Specific Rotation	Contact for details
Single Impurity (HPLC)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.