Description

1-(4-Chlorobenzoyl)-2-Methyl-5-[(Trimethylsilyl)Oxy]-1H-Indole-3-Acetic Acid Trimethylsilyl Ester is a key synthetic intermediate featuring a protected indole-3-acetic acid core, designed for advanced pharmaceutical research and development. Its value lies in its role as a versatile building block for creating novel therapeutic agents, particularly in the fields of anti-inflammatory and analgesic drug discovery. This compound is essential for medicinal chemists and process development scientists in pharmaceutical and biotechnology companies who require high-purity, structurally complex intermediates for API synthesis.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of non-steroidal anti-inflammatory drugs (NSAIDs) and other bioactive indole derivatives.
• Medicinal Chemistry Research: Used as a protected scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of candidate drug molecules.
• Process Chemistry & Scale-up: Serves as a key intermediate in the development and optimization of scalable manufacturing routes for active pharmaceutical ingredients (APIs).
• Reference Standard: Employed as an analytical standard for quality control and method validation during API production and regulatory submissions.
• Custom Synthesis: A starting material for the contract synthesis of specialized, proprietary compounds for client-specific drug discovery programs.

Basic Information

Product Name	1-(4-Chlorobenzoyl)-2-Methyl-5-[(Trimethylsilyl)Oxy]-1H-Indole-3-Acetic Acid Trimethylsilyl Ester
CAS No.	55471-00-6
Molecular Formula	C24H28ClNO4Si2
Molecular Weight	494.11 g/mol
Synonyms	5-(Trimethylsilyloxy)-1-(4-chlorobenzoyl)-2-methyl-1H-indole-3-acetic Acid Trimethylsilyl Ester; 1-(p-Chlorobenzoyl)-2-methyl-5-(trimethylsiloxy)indole-3-acetic Acid Trimethylsilyl Ester; Indomethacin Silyl Ester Derivative; 1H-Indole-3-acetic Acid, 1-(4-Chlorobenzoyl)-2-methyl-5-[(trimethylsilyl)oxy]-, Trimethylsilyl Ester; 55471-00-6; Trimethylsilyl 1-(4-Chlorobenzoyl)-2-methyl-5-(trimethylsilyloxy)-1H-indole-3-acetate
EINECS	Contact for details

Quality Control

Our 1-(4-Chlorobenzoyl)-2-Methyl-5-[(Trimethylsilyl)Oxy]-1H-Indole-3-Acetic Acid Trimethylsilyl Ester is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP guidelines for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions, such as in a glovebox or under an inert atmosphere, for long-term storage or after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.