Description

3β,28-Bis[(Tetrahydro-2H-Pyran-2-Yl)Oxy]Lup-20(29)-En-21β-Ol CAS NO 55401-93-9 is a key protected intermediate in the synthesis of bioactive triterpenoids, particularly betulin derivatives. This compound is valued for its role in enabling complex chemical transformations while preserving critical functional groups for downstream pharmaceutical applications. It is primarily sought by research institutions and pharmaceutical development companies engaged in the synthesis of novel anti-inflammatory, antiviral, and anticancer agents.

Application

• Pharmaceutical Intermediate: A critical building block for the semi-synthesis of betulinic acid and its analogs, which are under investigation for their therapeutic potential.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new drug candidates with modified pharmacokinetic properties.
• Academic Synthesis: Serves as a standard substrate in organic chemistry laboratories for studying protective group chemistry and complex molecular transformations.
• Precursor for Biologically Active Compounds: Enables the targeted synthesis of derivatives with potential activity against HIV, malaria, and various cancer cell lines.
• Process Development: Utilized in scaling up synthetic routes for triterpenoid-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	3β,28-Bis[(Tetrahydro-2H-Pyran-2-Yl)Oxy]Lup-20(29)-En-21β-Ol
CAS No.	55401-93-9
Molecular Formula	C40H64O5
Molecular Weight	624.9 g/mol
Synonyms	3β,28-Bis-O-(tetrahydropyran-2-yl)betulin; 3β,28-Di-O-tetrahydropyran-2-ylbetulin; 3β,28-Bis(tetrahydropyran-2-yloxy)lup-20(29)-en-21β-ol; Betulin 3,28-bis(tetrahydropyran-2-yl ether); THP-protected Betulin; Lup-20(29)-en-3β,28-diol, 3,28-bis[(tetrahydro-2H-pyran-2-yl)oxy]-; (3β,21β)-3,28-Bis[(tetrahydro-2H-pyran-2-yl)oxy]lup-20(29)-en-21-ol
EINECS	Contact for details

Quality Control

Our 3β,28-Bis[(Tetrahydro-2H-Pyran-2-Yl)Oxy]Lup-20(29)-En-21β-Ol is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is stable under inert atmosphere but should be kept away from strong acids and oxidizing agents. For long-term storage, consider storing under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.