Description

3-[[Bis[(Trimethylsilyl)Oxy]Phosphinyl]Oxy]-2,2-Dimethoxypropanoic Acid Trimethylsilyl Ester is a highly specialized organosilicon-protected phosphonate reagent, crucial for introducing protected phosphate and carboxylic acid functionalities in complex synthetic sequences. Its value lies in enabling precise, multi-step synthesis under mild conditions, particularly in sensitive applications where traditional acidic or basic protecting groups are incompatible. This compound is essential for researchers and manufacturers in pharmaceutical development, nucleotide chemistry, and the synthesis of complex bioactive molecules and prodrugs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of nucleotide analogs, antiviral agents, and prodrugs with phosphate ester linkages.
• Peptide & Protein Modification: Used to introduce phosphonate or protected carboxylate groups onto amino acids or peptides for biochemical studies and drug conjugates.
• Organophosphorus Chemistry: Serves as a versatile reagent for the preparation of complex phosphonates, phosphinates, and their derivatives under silyl-protecting conditions.
• Material Science Precursor: Potential use in creating functionalized surfaces or polymers with specific phosphate or carboxylate anchoring points.
• Chemical Biology Probes: Enables the synthesis of labeled or modified biomolecules for mechanistic studies and diagnostic applications.
• Agrochemical Synthesis: Intermediate in the development of advanced herbicides or plant growth regulators containing phosphonate moieties.

Basic Information

Product Name	3-[[Bis[(Trimethylsilyl)Oxy]Phosphinyl]Oxy]-2,2-Dimethoxypropanoic Acid Trimethylsilyl Ester
CAS No.	55401-57-5
Molecular Formula	C14H35NO8PSi3 (Note: Formula may vary based on isomer; contact for confirmed structure)
Molecular Weight	Contact for details
Synonyms	Trimethylsilyl 3-[[bis(trimethylsilyloxy)phosphinyl]oxy]-2,2-dimethoxypropanoate; 2,2-Dimethoxy-3-phosphonooxypropionic Acid Tris(trimethylsilyl) Ester; Tris(trimethylsilyl) 2,2-dimethoxy-3-phosphonoxypropionate; Propanoic acid, 3-[[bis[(trimethylsilyl)oxy]phosphinyl]oxy]-2,2-dimethoxy-, trimethylsilyl ester; TMS-Protected Phosphonopropionate Ester; CAS 55401-57-5
EINECS	Contact for details

Quality Control

Our production of 3-[[Bis[(Trimethylsilyl)Oxy]Phosphinyl]Oxy]-2,2-Dimethoxypropanoic Acid Trimethylsilyl Ester adheres to stringent quality protocols suitable for research and development use. Each batch is characterized and tested to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay (by NMR or HPLC), identity (by IR or NMR), and purity profile are available upon request. We support compliance with relevant ICH guidelines for stability and impurity profiling.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) when opening to prevent decomposition. Keep away from heat and incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR / NMR)	Conforms to reference spectrum
Assay (HPLC / NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.