Description

1-Chloro-4-Fluoro-Benzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its value lies in the synergistic reactivity of the chlorine and fluorine substituents, enabling selective functionalization for the creation of complex molecules. This intermediate is essential for manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it serves as a key precursor for active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical starting material for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drugs where the fluorine atom enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging the halogenated benzene core for effective crop protection agents.
• Liquid Crystal & OLED Materials: Serves as a foundational unit in the manufacture of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, contributing to improved electronic properties.
• Polymer & Resin Modifier: Employed to introduce halogenated phenyl groups into polymer chains, modifying properties such as flame retardancy, chemical resistance, and thermal stability.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) due to the differential reactivity of the C-Cl and C-F bonds.
• Chemical Research & Development: A valuable reagent in R&D laboratories for exploring new synthetic pathways and creating novel fluorinated compounds.

Basic Information

Item	Details
Product Name	1-Chloro-4-Fluoro-Benzene
CAS No.	55256-17-2
Molecular Formula	C6H4ClF
Molecular Weight	130.55 g/mol
Synonyms	4-Chlorofluorobenzene; p-Chlorofluorobenzene; 1-Fluoro-4-chlorobenzene; 4-Fluorochlorobenzene; p-Fluorochlorobenzene; FCB; 4-Fluoro-1-chlorobenzene; Benzene, 1-chloro-4-fluoro-
EINECS	Contact for details

Quality Control

Our 1-Chloro-4-Fluoro-Benzene is manufactured under a stringent quality management system. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR analysis, to ensure high purity and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and other regulated materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.5%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Total impurities ≤ 1.5%
Density (at 20°C)	~1.25 g/cm³
Boiling Point	~127°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.