Description

N(4)-Glucopyranosylsulfamethazine is a chemically modified sulfonamide derivative, specifically a glucosylated form of sulfamethazine. This structural modification is of significant interest for its potential to alter pharmacokinetic properties, such as solubility and metabolic stability, compared to the parent compound. It is primarily utilized in advanced pharmaceutical research and development, particularly for investigating prodrug strategies and novel antimicrobial agents targeting veterinary and human health sectors.

Application

• Pharmaceutical Research & Development: As a key intermediate or model compound for studying glucosylation effects on drug delivery, bioavailability, and metabolic pathways of sulfonamides.
• Prodrug Synthesis: Serving as a precursor or active moiety in the design and synthesis of targeted prodrugs aimed at improving therapeutic efficacy and reducing side effects.
• Antimicrobial Studies: Used in biochemical and microbiological assays to evaluate the structure-activity relationship (SAR) of glycosylated sulfonamide antibiotics.
• Analytical Reference Standard: Employed as a high-purity standard in HPLC, LC-MS, or NMR for quality control and method development in analytical laboratories.
• Veterinary Medicine Development: Investigated for potential applications in developing next-generation antibacterial treatments for livestock, addressing issues like residue and resistance.
• Bioconjugation & Chemical Biology: Acting as a building block in bioconjugation chemistry for labeling or targeting studies due to its reactive functional groups.

Basic Information

Product Name	N(4)-Glucopyranosylsulfamethazine
CAS No.	55101-26-3
Molecular Formula	C23H28N4O8S
Molecular Weight	520.56 g/mol
Synonyms	4-[(4,6-Dimethyl-2-pyrimidinyl)amino]-N-(β-D-glucopyranosyl)benzenesulfonamide; Sulfamethazine N4-β-D-glucopyranoside; Glucosylsulfamethazine; N4-Glucosylsulfamethazine; N(4)-β-D-Glucopyranosylsulfamethazine; 1-[4-[(4,6-Dimethylpyrimidin-2-yl)sulfamoyl]phenyl]-1-deoxy-β-D-glucopyranosylamine; Sulfamethazine glucoside
EINECS	Contact for details

Quality Control

Our N(4)-Glucopyranosylsulfamethazine is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency. Each lot undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, IR). A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP guidelines where applicable to meet the stringent requirements of pharmaceutical and research customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.