Description

4-Methoxy-α-(Trimethylsiloxy)Benzeneacetic Acid Methyl Ester is a specialized organosilicon intermediate of significant importance in advanced synthetic chemistry. Its core value lies in its role as a protected synthon for arylacetic acid derivatives, enabling precise and efficient construction of complex molecules. This compound is primarily needed by research and development teams, as well as production chemists, in the pharmaceutical and fine chemical industries for the synthesis of active pharmaceutical ingredients (APIs) and novel organic materials.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug molecules, particularly non-steroidal anti-inflammatory drugs (NSAIDs) and other arylacetic acid-based therapeutics.
• Fine Chemical Synthesis: Used in the preparation of advanced organic compounds where the protection of the carboxylic acid group is required during sensitive reaction sequences.
• Agrochemical Research: Serves as a precursor in the development of new herbicides and plant growth regulators that utilize modified arylacetic acid structures.
• Material Science: Employed in the synthesis of specialty polymers and liquid crystals where silicon-containing aromatic monomers are incorporated to modify material properties.
• Academic & Contract Research: A valuable reagent for methodological development in organic synthesis and catalysis within university and CRO (Contract Research Organization) laboratories.

Basic Information

Item	Details
Product Name	4-Methoxy-α-(Trimethylsiloxy)Benzeneacetic Acid Methyl Ester
CAS No.	55000-34-5
Molecular Formula	C13H20O4Si
Molecular Weight	268.38 g/mol
Synonyms	Methyl 2-(4-methoxyphenyl)-2-[(trimethylsilyl)oxy]acetate; Methyl (4-methoxyphenyl)(trimethylsiloxy)acetate; 2-(4-Methoxyphenyl)-2-[(trimethylsilyl)oxy]acetic acid methyl ester; Anisole, α-[(trimethylsilyl)oxy]-α-(methoxycarbonyl)-; α-(Trimethylsiloxy)-4-methoxybenzeneacetic acid methyl ester; p-Methoxy-α-(trimethylsiloxy)benzeneacetic acid methyl ester; TMSE Anisyl Glycolate Methyl Ester
EINECS	Contact for details

Quality Control

Our 4-Methoxy-α-(Trimethylsiloxy)Benzeneacetic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.