Description

tert-Butyldimethylsilylimidazole (CAS NO 54925-64-3) is a highly reactive silylating agent primarily used for the protection of hydroxyl groups in organic synthesis. Its core value lies in its ability to introduce the robust tert-butyldimethylsilyl (TBDMS) protecting group, which offers excellent stability under a wide range of reaction conditions. This compound is an essential intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries, enabling the precise construction of complex molecules.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for protecting sensitive alcohol functionalities during multi-step synthesis of active pharmaceutical ingredients (APIs).
• Nucleoside and Carbohydrate Chemistry: Used to protect the hydroxyl groups of sugars and nucleosides in the preparation of antiviral and anticancer drug candidates.
• Steroid and Natural Product Modification: Facilitates selective functionalization in the synthesis of complex steroids and other natural product derivatives.
• Polymer Science: Acts as a functionalization agent or initiator modifier in the development of specialty polymers and silicones.
• Agrochemical Manufacturing: Employed in the synthesis of advanced herbicides, fungicides, and plant growth regulators requiring selective protection strategies.
• Peptide Synthesis: Used for the temporary protection of serine, threonine, or tyrosine side chains in solid-phase peptide synthesis (SPPS).
• Material Science Research: Serves as a precursor for surface modification of silica and other metal oxides to alter surface properties.

Basic Information

Product Name	tert-Butyldimethylsilylimidazole
CAS No.	54925-64-3
Molecular Formula	C9H20N2Si
Molecular Weight	184.36 g/mol
Synonyms	TBDMS-Imidazole; 1-[(1,1-Dimethylethyl)dimethylsilyl]-1H-imidazole; tert-Butyl(chloro)dimethylsilane Imidazole Complex; N-(tert-Butyldimethylsilyl)imidazole; TBDMSIm; tert-Butyldimethylsilyl Imidazolide; Imidazole, 1-[(1,1-dimethylethyl)dimethylsilyl]-; TBS-Imidazole
EINECS	Contact for details

Quality Control

Our tert-Butyldimethylsilylimidazole is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition and maintain optimal reactivity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.