Description

2-Phenyl-2H-Tetrazole-5-Carboxylic Acid is a high-value heterocyclic building block and versatile synthetic intermediate. This compound is critical for applications requiring the introduction of a tetrazole moiety, which is a key pharmacophore in medicinal chemistry and a stable bioisostere for carboxylic acids. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing tetrazole rings for angiotensin II receptor antagonists (e.g., Sartans) and other drug candidates.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the tetrazole group enhances biological activity and stability.
• Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers, coordination polymers (MOFs), and high-energy materials.
• Chemical Biology & Proteomics: Employed as a bioorthogonal reagent or a click chemistry component for labeling and modifying biomolecules.
• Ligand in Catalysis: Acts as a precursor for N-donor ligands used in transition metal catalysis for various organic transformations.
• Academic & Industrial R&D: A fundamental reagent for methodological development in organic synthesis and heterocyclic chemistry research.

Basic Information

Product Name	2-Phenyl-2H-Tetrazole-5-Carboxylic Acid
CAS No.	54798-92-4
Molecular Formula	C8H6N4O2
Molecular Weight	190.16 g/mol
Synonyms	5-Carboxy-2-phenyl-2H-tetrazole; 2-Phenyltetrazole-5-carboxylic acid; 2-Phenyl-1,2,3,4-tetrazole-5-carboxylic acid; 2-Phenyl-2H-tetrazole-5-carboxylic acid; 5-Tetrazolecarboxylic acid, 2-phenyl-; PTCA; 2-Phenyl-5-tetrazolecarboxylic acid; 1-Phenyl-1H-tetrazole-5-carboxylic acid (tautomer)
EINECS	Contact for details

Quality Control

Our 2-Phenyl-2H-Tetrazole-5-Carboxylic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) documenting all critical parameters are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.