Description

(3Ar,4S,5R,6As)-Hexahydro-5-Hydroxy-4-(Hydroxymethyl)-2H-Cyclopenta[B]Furan-2-One is a high-purity, stereochemically defined chiral building block and intermediate of significant value in advanced organic synthesis. Its complex fused-ring structure, featuring multiple functional groups, makes it a critical precursor for the development of novel pharmaceutical compounds, particularly in nucleoside and carbocyclic analog research. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce specific stereochemistry and molecular complexity into their target molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of potent antiviral and anticancer agents, especially carbocyclic nucleoside analogs.
• Advanced Organic Synthesis: Used as a versatile building block for constructing complex, polycyclic molecular architectures with defined stereocenters.
• Agrochemical Research: Employed in the development of new, biologically active compounds with specific modes of action.
• Process Chemistry & Scale-Up: Provides a defined starting point for optimizing synthetic routes from laboratory to pilot and commercial scale.
• Academic & Institutional R&D: A valuable tool for research in medicinal chemistry, total synthesis, and methodology development.
• Fine Chemical Production: Used in the manufacture of specialty chemicals requiring high stereochemical purity.

Basic Information

Product Name	(3Ar,4S,5R,6As)-Hexahydro-5-Hydroxy-4-(Hydroxymethyl)-2H-Cyclopenta[B]Furan-2-One
CAS No.	54423-47-1
Molecular Formula	C8H12O4
Molecular Weight	172.18 g/mol
Synonyms	(-)-Carbocyclic Oxetanocin H; (1S,2R,3S,4R)-4-(Hydroxymethyl)cyclopentane-1,2,3-triol 2,3-Carbonate; 4-(Hydroxymethyl)-2-oxabicyclo[3.3.0]oct-6-en-3-one derivative; Cyclopenta[B]furan-2-one, hexahydro-5-hydroxy-4-(hydroxymethyl)-, (3aR,4S,5R,6aS)-rel-; Chiral Cyclopentane Lactone; COH Derivative; Carbocyclic Oxetanocin Precursor
EINECS	Contact for details

Quality Control

Our (3Ar,4S,5R,6As)-Hexahydro-5-Hydroxy-4-(Hydroxymethyl)-2H-Cyclopenta[B]Furan-2-One is produced under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity analysis, to ensure it meets the exacting standards required for pharmaceutical R&D and advanced synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake, which may affect stability and handling. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.