Description

Etonogestrel is a potent, third-generation progestin widely recognized for its high selectivity and efficacy. This active pharmaceutical ingredient (API) is a cornerstone in the development of long-acting, reversible contraceptive solutions, offering significant therapeutic value. It is primarily utilized by pharmaceutical manufacturers and research institutions in the global healthcare sector for the formulation of hormonal implants and intrauterine systems, where consistent quality and reliable supply are paramount.

Application

• Hormonal Contraceptive Implants: The primary and most significant application is as the active progestin in subdermal contraceptive implants (e.g., Nexplanon®/Implanon®), providing long-term birth control.
• Intrauterine Systems (IUS): Used in hormone-releasing intrauterine devices for contraception and treatment of heavy menstrual bleeding.
• Pharmaceutical R&D: Serves as a key intermediate or reference standard in the research and development of novel progestin-based therapies.
• Hormone Replacement Therapy (HRT): Investigated for use in combination regimens for managing menopausal symptoms.
• Veterinary Pharmaceuticals: Potential application in animal health for fertility control and hormonal regulation.
• Reference Standard: Used in analytical laboratories for quality control testing, method development, and regulatory compliance.

Basic Information

Product Name	Etonogestrel
CAS No.	54048-10-1
Molecular Formula	C22H28O2
Molecular Weight	324.46 g/mol
Synonyms	3-Ketodesogestrel; Org 3236; 13-Ethyl-11-methylene-18,19-dinor-17α-pregn-4-en-20-yn-17-ol; 11-Methylene-17α-ethynyl-17β-hydroxy-18-methyl-19-nor-4-androsten-3-one; 17α-Ethynyl-13-ethyl-11-methylene-18,19-dinor-17β-hydroxy-4-androsten-3-one; Desogestrel metabolite; 11-Methylenedesogestrel
EINECS	Contact for details

Quality Control

Our Etonogestrel is manufactured under strict quality management systems, targeting compliance with ICH Q7 guidelines and relevant pharmacopoeial standards (e.g., USP, EP). Every batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC. A Certificate of Analysis (COA) detailing all specifications and results is provided to ensure full traceability and regulatory support for your projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept under conditions that minimize exposure to humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.