Description

(E)-5-Hydroxy-2-Pentenenitrile is a versatile chiral nitrile intermediate with significant synthetic utility. Its bifunctional nature, featuring both a hydroxyl group and a nitrile moiety, makes it a valuable building block for constructing complex molecular architectures. This compound is particularly relevant for researchers and manufacturers in the pharmaceutical and fine chemical industries seeking to develop active pharmaceutical ingredients (APIs) and advanced organic compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of various therapeutic agents, including potential antiviral and cardiovascular drugs.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, leveraging its nitrile functionality.
• Fine Chemical Building Block: Employed in asymmetric synthesis and the construction of complex natural products and specialty chemicals.
• Ligand and Catalyst Precursor: Serves as a starting material for the development of novel chiral ligands and organocatalysts.
• Polymer Modification: Can be used to introduce functional groups into polymer chains for specialty material applications.

Basic Information

Product Name	(E)-5-Hydroxy-2-Pentenenitrile
CAS No.	53778-56-6
Molecular Formula	C5H7NO
Molecular Weight	97.12 g/mol
Synonyms	(E)-4-Cyano-3-buten-1-ol; (E)-5-Hydroxypent-2-enenitrile; 2-Pentenenitrile, 5-hydroxy-, (E)-; 5-Hydroxy-2-pentenenitrile, (E)-; (E)-5-Hydroxy-2-pentenentrile; trans-5-Hydroxy-2-pentenenitrile; 3-Buten-1-ol, 4-cyano-, (E)-
EINECS	Contact for details

Quality Control

Our (E)-5-Hydroxy-2-Pentenenitrile is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.