Description

1-(Difluoromethyl)Naphthalene is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity and electronic properties imparted by the difluoromethyl group, enabling precise molecular modifications. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, as well as in materials science for creating functional organic materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting enzyme inhibition or receptor modulation.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a fluorinated core structure in the synthesis of organic semiconductors and liquid crystal compounds for electronic displays.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, such as Suzuki or Negishi couplings, to introduce the naphthalene-difluoromethyl moiety into complex molecules.
• Fluorine Chemistry Research: A valuable reagent for studying the effects of gem-difluorination on aromatic systems and reaction pathways.
• Polymer & Resin Modifier: Can be incorporated into polymer backbones to alter physical properties like thermal stability, solubility, or refractive index.

Basic Information

Product Name	1-(Difluoromethyl)Naphthalene
CAS No.	53731-26-3
Molecular Formula	C₁₁H₈F₂
Molecular Weight	178.18 g/mol
Synonyms	1-(Difluoromethyl)naphthalene; Naphthalene, 1-(difluoromethyl)-; α,α-Difluoro-1-naphthalenemethane; 1-Naphthyldifluoromethane; (1-Naphthyl)difluoromethane; Difluoro(1-naphthyl)methane; 1-(Difluoromethyl)naphthalene (DFMN)
EINECS	Contact for details

Quality Control

Our 1-(Difluoromethyl)Naphthalene is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatography and spectroscopy, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.