Description

4-Nitrobenzo-18-Crown-6 is a functionalized crown ether derivative, specifically a nitro-substituted benzo-18-crown-6. This compound is a crucial synthetic intermediate and a selective complexing agent, valued for its ability to bind specific cations, particularly potassium ions, with high affinity. It is primarily utilized by researchers and manufacturers in the fields of supramolecular chemistry, ion-selective sensors, phase-transfer catalysis, and advanced material science. The nitro group provides a versatile handle for further chemical modification, making it a key building block for developing novel host-guest systems and functional materials.

Application

• Ion-Selective Electrodes (ISEs) and Sensors: Acts as a key ionophore in membrane formulations for the selective detection and quantification of potassium and other alkali metal ions.
• Phase-Transfer Catalysis (PTC): Facilitates the transfer of ionic reagents between immiscible phases in organic synthesis, enhancing reaction rates and yields.
• Supramolecular Chemistry Research: Serves as a fundamental building block for constructing more complex molecular hosts, rotaxanes, and catenanes.
• Metal Ion Extraction and Separation: Used in liquid-liquid extraction processes to selectively separate and concentrate specific metal cations from complex mixtures.
• Polymer and Material Modification: Incorporated into polymers or surfaces to create ion-sensing films or materials with specific ion-binding properties.
• Analytical Chemistry: Employed as a chiral selector or complexing agent in chromatographic separations and capillary electrophoresis.
• Chemical Synthesis Intermediate: The nitro group can be reduced to an amine, providing a pathway to synthesize a wide range of functionalized crown ether derivatives.

Basic Information

Product Name	4-Nitrobenzo-18-Crown-6
CAS No.	53408-96-1
Molecular Formula	C16H23NO8
Molecular Weight	357.36 g/mol
Synonyms	4-Nitrobenzo-18-crown-6 ether; 2,3,5,6,8,9,11,12-Octahydro-1,4,7,10,13,16-benzobexaoxacyclooctadecin-2-yl Nitro Derivative; Benzo-18-crown-6, 4-nitro-; 1,4,7,10,13,16-Hexaoxacyclooctadec-2-ylmethyl Nitrobenzene; 4-Nitrobenzo-18-crown-6 Ether; Potassium Ionophore I; Nitrobenzo-18-crown-6; 4-Nitro-B18C6
EINECS	Contact for details

Quality Control

Our 4-Nitrobenzo-18-Crown-6 is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity, identity confirmation, and batch-to-batch consistency. Standard quality checks include HPLC for purity, IR and NMR for structural identification, and loss on drying. A comprehensive Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment. We can support development and production needs requiring compliance with various internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	98 - 102 °C
Loss on Drying	≤ 0.5 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.