Description

(3β,20α)-17α-Ethyl-11-Methoxy-18β-[(3,4,5-Trimethoxybenzoyl)Oxy]Yohimban-16β-Carboxylic Acid Methyl Ester is a complex, semi-synthetic indole alkaloid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical high-purity intermediate or reference standard for the synthesis and study of novel therapeutic agents targeting the central nervous system. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of specialized APIs and investigational new drugs.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex, biologically active indole alkaloids and potential drug candidates.
• Reference Standard: Used in analytical chemistry for method development, validation, and quality control (HPLC, LC-MS) of related compounds in research and manufacturing.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore modifications of the yohimbane core for enhanced pharmacological properties.
• Biochemical Research: Investigated for its interaction with specific neurotransmitter receptors and enzymes as a tool compound in neuropharmacology.
• Process Development: Serves as a benchmark material for scaling up synthetic routes and optimizing production processes in a GMP or non-GMP environment.

Basic Information

Product Name	(3β,20α)-17α-Ethyl-11-Methoxy-18β-[(3,4,5-Trimethoxybenzoyl)Oxy]Yohimban-16β-Carboxylic Acid Methyl Ester
CAS No.	53198-86-0
Molecular Formula	C35H42N2O8
Molecular Weight	618.72 g/mol
Synonyms	Methyl (3β,20α)-17α-ethyl-11-methoxy-18β-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16β-carboxylate; 17α-Ethyl-11-methoxy-18β-(3,4,5-trimethoxybenzoyloxy)yohimban-16β-carboxylic acid methyl ester; Ajmalicine derivative; Trimethoxybenzoyl ajmalicine methyl ester; Yohimban-16β-carboxylic acid, 17α-ethyl-11-methoxy-18β-[(3,4,5-trimethoxybenzoyl)oxy]-, methyl ester, (3β,20α)-; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our (3β,20α)-17α-Ethyl-11-Methoxy-18β-[(3,4,5-Trimethoxybenzoyl)Oxy]Yohimban-16β-Carboxylic Acid Methyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for research and development use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.