Description

[α-[(Trimethylsilyl)Amino]-4-(Trimethylsiloxy)Phenethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a sophisticated organosilicon-protected phosphonic acid derivative, serving as a critical synthetic intermediate and protecting group reagent. Its value lies in enabling complex organic transformations, particularly in the synthesis of sensitive bioactive molecules and advanced materials, by safeguarding reactive functional groups. This compound is essential for researchers and manufacturers in pharmaceutical development, agrochemical synthesis, and advanced material science who require high-purity, specialized building blocks.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, particularly those containing phosphonate or amino acid motifs.
• Peptide & Nucleotide Chemistry: Used as a protecting group reagent for amino and phosphonic acid functionalities during solid-phase and solution-phase synthesis.
• Agrochemical Synthesis: Intermediate in the production of advanced herbicides, plant growth regulators, and other bioactive agrochemicals.
• Material Science Precursor: Serves as a precursor for surface modification agents, metal-organic frameworks (MOFs), and specialty polymers.
• Chemical Research & Development: A valuable tool for academic and industrial R&D labs exploring new synthetic methodologies and organophosphorus chemistry.
• Ligand Synthesis: Used in the preparation of specialized ligands for catalysis and metal complexation.

Basic Information

Product Name	[α-[(Trimethylsilyl)Amino]-4-(Trimethylsiloxy)Phenethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	53044-43-2
Molecular Formula	C20H42NO4PSi4
Molecular Weight	528.95 g/mol
Synonyms	Phosphonic acid, P-[2-[4-[(trimethylsilyl)oxy]phenyl]-1-[(trimethylsilyl)amino]ethyl]-, bis(trimethylsilyl) ester; α-[(Trimethylsilyl)amino]-4-(trimethylsiloxy)phenethylphosphonic acid bis(trimethylsilyl) ester; TMS-protected phosphonate; N,O-Bis(trimethylsilyl) tyrosine phosphonate derivative; (2-Amino-2-(4-hydroxyphenyl)ethyl)phosphonic acid, N,O,P-tris(trimethylsilyl) derivative; TMS-Tyr(PO3TMS2)-OTMS
EINECS	Contact for details

Quality Control

Our [α-[(Trimethylsilyl)Amino]-4-(Trimethylsiloxy)Phenethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and production use. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical and advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opened to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.