Description

(S)-2-Chloromandelic Acid is a high-purity chiral building block and resolving agent of significant importance in asymmetric synthesis. Its value lies in its utility for the preparation of enantiomerically pure pharmaceuticals and fine chemicals, enabling critical stereochemical control. This compound is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical, agrochemical, and advanced material industries.

Application

• Chiral Resolution Agent: Used for the separation of racemic mixtures of amines and other basic compounds.
• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a specific (S)-configuration.
• Asymmetric Synthesis: Serves as a precursor or auxiliary in catalytic and stoichiometric asymmetric reactions to induce chirality.
• Agrochemical Research: Employed in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Ligand Synthesis: Used to prepare chiral ligands for transition metal catalysis.
• Reference Standard: Acts as a high-purity standard for analytical method development and quality control in chiral analysis.

Basic Information

Product Name	(S)-2-Chloromandelic Acid
CAS No.	52950-19-3
Molecular Formula	C8H7ClO3
Molecular Weight	186.59 g/mol
Synonyms	(S)-(-)-2-Chloromandelic Acid; (S)-α-Chloromandelic Acid; (2S)-2-Chloro-2-hydroxy-2-phenylethanoic Acid; (S)-2-Chloro-2-hydroxy-2-phenylacetic Acid; L-2-Chloromandelic Acid; (S)-CMA; (S)-2-Chloro-2-phenylglycolic Acid
EINECS	Contact for details

Quality Control

Our (S)-2-Chloromandelic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity (enantiomeric excess) and chemical purity determination by HPLC, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Melting Point	118°C - 122°C
Loss on Drying	≤0.5%
Residue on Ignition (Sulfated Ash)	≤0.1%
Heavy Metals (as Pb)	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.