Description

(R)-(-)-2-Chloromandelic Acid is a high-purity chiral building block and resolving agent of significant importance in asymmetric synthesis. Its value lies in its utility for the preparation of enantiomerically pure pharmaceuticals and fine chemicals, enabling the development of targeted therapies. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require optically active intermediates.

Application

• Chiral Resolution Agent: Used for the separation of racemic mixtures of amines and other basic compounds.
• Pharmaceutical Intermediate: A key building block in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly for cardiovascular and central nervous system drugs.
• Asymmetric Synthesis: Serves as a precursor for chiral catalysts and ligands used in stereoselective reactions.
• Agrochemical Synthesis: Employed in the production of optically active herbicides and pesticides.
• Research & Development: A valuable tool in academic and industrial R&D for exploring new synthetic methodologies and chiral compounds.
• Fine Chemical Production: Used in the manufacture of specialty chemicals requiring specific stereochemistry.

Basic Information

Product Name	(R)-(-)-2-Chloromandelic Acid
CAS No.	52950-18-2
Molecular Formula	C8H7ClO3
Molecular Weight	186.59 g/mol
Synonyms	(R)-2-Chloro-2-hydroxy-2-phenylacetic Acid; (R)-(-)-2-Chloro-2-hydroxy-2-phenylacetic Acid; (R)-α-Chloromandelic Acid; (R)-O-Chloromandelic Acid; (2R)-2-Chloro-2-hydroxy-2-phenylacetic Acid; (R)-2-Chloromandelic Acid; (R)-CMA; (R)-(-)-CMA
EINECS	Contact for details

Quality Control

Our (R)-(-)-2-Chloromandelic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity (enantiomeric excess) and chemical purity determination by HPLC, to ensure it meets the high standards required for pharmaceutical applications. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	118 - 122 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.