Description

4Aα,6α-Dihydroxy-1-Methyl-8-Methylenegibbane-1α,10β-Dicarboxylic Acid 1,4A-Lactone is a high-purity gibbane-type diterpenoid lactone derivative, serving as a critical advanced intermediate in the synthesis of complex natural products and pharmaceuticals. Its unique, functionalized gibbane skeleton makes it a valuable building block for research and development in medicinal chemistry, particularly for exploring novel bioactive compounds. This compound is essential for specialized chemical manufacturers, academic research institutions, and pharmaceutical R&D departments focused on terpenoid synthesis and drug discovery.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of gibberellin analogs and other bioactive diterpenoids with potential therapeutic applications.
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities.
• Natural Product Synthesis: Serves as a crucial building block for the total or semi-synthesis of complex natural products within the gibberellin family.
• Biochemical Research: Employed in studies investigating plant hormone pathways and the biological activity of gibbane-related compounds.
• Reference Standard: Used as an analytical standard in chromatography (HPLC, GC) for quality control and method development in related compound analysis.
• Specialty Chemical Manufacturing: Intermediate for producing custom fine chemicals and advanced materials requiring a functionalized diterpene core.

Basic Information

Product Name	4Aα,6α-Dihydroxy-1-Methyl-8-Methylenegibbane-1α,10β-Dicarboxylic Acid 1,4A-Lactone
CAS No.	52846-39-6
Molecular Formula	C20H24O6
Molecular Weight	360.40 g/mol
Synonyms	1,4A-Lactone of 4Aα,6α-Dihydroxy-1-Methyl-8-Methylenegibbane-1α,10β-Dicarboxylic Acid; 8-Methylenegibbane-1α,10β-dicarboxylic acid, 4aα,6α-dihydroxy-1-methyl-, 1,4a-lactone; Gibbane-1α,10β-dicarboxylic acid, 4aα,6α-dihydroxy-1-methyl-8-methylene-, 1,4a-lactone; 4aα,6α-Dihydroxy-1-methyl-8-methylenegibbane-1α,10β-dicarboxylic acid γ-lactone; A gibberellin A4 catabolite derivative.
EINECS	Contact for details

Quality Control

Our 4Aα,6α-Dihydroxy-1-Methyl-8-Methylenegibbane-1α,10β-Dicarboxylic Acid 1,4A-Lactone is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic methods (NMR, IR, MS) for structural confirmation, to ensure it meets exacting standards for research and synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.