Description

n-α-T-Butyloxycarbonyl-L-Leucinyl-Diazomethane, (S)-3-Boc-Amino-1-Diazo-5-Methyl-2-Hexanone is a specialized, high-purity amino acid derivative featuring a diazomethane functional group. This compound is a critical building block in advanced organic synthesis, particularly valued for its role in constructing complex peptide and peptidomimetic structures. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical sectors who require precise and reliable intermediates for drug discovery and development.

Application

• Peptide Synthesis: A key protected intermediate for the solid-phase and solution-phase synthesis of leucine-containing peptides and peptidomimetics.
• Pharmaceutical Research: Used in the development of active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other therapeutic agents targeting protein-protein interactions.
• Chemical Biology Probes: Serves as a precursor for photoaffinity labeling agents and cross-linkers used to study enzyme mechanisms and protein structures.
• Agrochemical Development: Employed as a synthetic intermediate in the creation of novel bioactive compounds with pesticidal or herbicidal activity.
• Academic Research: A valuable reagent for methodological studies in organic chemistry, exploring new C-C and C-N bond-forming reactions via carbene or metal-carbenoid intermediates.

Basic Information

Product Name	n-α-T-Butyloxycarbonyl-L-Leucinyl-Diazomethane, (S)-3-Boc-Amino-1-Diazo-5-Methyl-2-Hexanone
CAS No.	52716-48-0
Molecular Formula	C₁₃H₂₃N₃O₄
Molecular Weight	285.34 g/mol
Synonyms	Boc-Leu-CHN₂; (S)-3-((tert-Butoxycarbonyl)amino)-1-diazo-5-methyl-2-hexanone; N-(tert-Butoxycarbonyl)-L-leucine diazomethyl ketone; Boc-L-leucine diazomethyl ketone; L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-, diazomethyl ketone; 1-Diazo-3-[(2-methyl-2-propanyl)oxycarbonyl]amino-5-methyl-2-hexanone; (S)-1-Diazo-3-(Boc-amino)-5-methyl-2-hexanone
EINECS	Contact for details

Quality Control

Our production of n-α-T-Butyloxycarbonyl-L-Leucinyl-Diazomethane adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and cGMP applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and decomposition. Allow the container to reach room temperature in a desiccator before opening to minimize moisture ingress. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	[α]²⁰/D: -25° to -30° (c=1 in CHCl₃)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.