Description

Manumycin A is a potent and selective natural product inhibitor of farnesyltransferase, originally isolated from *Streptomyces parvulus*. This compound is a critical research tool for studying Ras oncogene signaling pathways and has shown significant promise in pre-clinical studies for its antitumor and antibacterial properties. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors for drug discovery, target validation, and mechanistic studies in oncology and microbiology.

Application

• Oncology Research: Used as a selective inhibitor to study the role of farnesyltransferase and Ras protein signaling in cancer cell proliferation and apoptosis.
• Antibacterial Agent Development: Investigated for its activity against various bacterial strains, including methicillin-resistant *Staphylococcus aureus* (MRSA).
• Signal Transduction Studies: A key reagent for elucidating post-translational modification pathways involving protein prenylation.
• Drug Discovery & Target Validation: Serves as a lead compound and pharmacological probe in high-throughput screening and hit-to-lead optimization campaigns.
• Biochemical Assays: Employed in in vitro enzymatic assays to measure farnesyltransferase inhibition.
• Academic & Institutional Research: Used in university and research institute laboratories for fundamental biological and chemical research.

Basic Information

Product Name	Manumycin A
CAS No.	52665-74-4
Molecular Formula	C31H38N2O7
Molecular Weight	550.65 g/mol
Synonyms	Manumycin; Antibiotic U 5648; U-5648; NSC 643046; (2E,4E,6E,8E)-10-[(3S,5S,6R)-3,5-Dihydroxy-6-methyloxan-2-yl]-N-[(1S)-1-[(2S,3S)-3-hydroxy-5-oxo-1,2-oxazolidin-2-yl]-3-methylbutyl]-2,4,6,8-decatetraenamide; L 631,529
EINECS	Contact for details

Quality Control

Every batch of Manumycin A is subjected to rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocols are designed to meet the exacting standards required for research and pre-clinical development. A comprehensive Certificate of Analysis (COA), detailing results for purity (HPLC), identity (NMR, MS), and related substances, is provided with each shipment to guarantee full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.