Description

Sulfamidine N1-Glucuronide is a key metabolite of the sulfonamide antibiotic, sulfamidine (sulfadimidine). This compound is of significant importance in pharmaceutical research and development, particularly for studying drug metabolism, pharmacokinetics, and excretion pathways. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in bioanalytical method development, metabolite identification, and regulatory toxicology studies.

Application

• Metabolite Reference Standard: Serves as a certified reference material (CRM) for the quantitative and qualitative analysis of sulfamidine metabolites in biological matrices.
• Pharmacokinetic & DMPK Studies: Essential for investigating the absorption, distribution, metabolism, and excretion (ADME) profile of sulfamidine in preclinical and clinical research.
• Bioanalytical Method Development: Used as a critical standard for developing and validating sensitive HPLC, LC-MS, or LC-MS/MS assays in plasma, urine, or tissue samples.
• Toxicology & Safety Assessment: Employed in studies to understand the safety and toxicity profile of sulfamidine and its metabolic pathway.
• Veterinary Drug Residue Testing: Acts as a standard in monitoring programs to detect and quantify sulfonamide residues in food-producing animals, ensuring food safety compliance.
• Regulatory Submission Support: Provides essential data for regulatory filings with agencies like the FDA and EMA by characterizing human metabolites.

Basic Information

Product Name	Sulfamidine N1-Glucuronide
CAS No.	52351-41-4
Molecular Formula	C19H24N4O8S
Molecular Weight	468.48 g/mol
Synonyms	Sulfadimidine N1-Glucuronide; N1-(4,6-Dimethyl-2-pyrimidinyl)sulfanilamide Glucuronide; 1-{[(4,6-Dimethylpyrimidin-2-yl)sulfamoyl]phenyl}glucopyranuronic Acid; Sulfamethazine N1-Glucuronide; Sulfadimidine Glucuronide Metabolite; N1-Glucuronosylsulfadimidine; SMPG
EINECS	Contact for details

Quality Control

Every batch of Sulfamidine N1-Glucuronide is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the stringent requirements for reference standard applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting critical parameters such as assay purity (by HPLC), identity confirmation (by NMR/MS), and impurity profiles. Our quality commitment supports compliance with GMP and ISO guidelines for research materials.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, consider desiccant and under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.