Description

4-(Trifluoromethyl)-1H-Pyrazole is a versatile fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique combination of the pyrazole scaffold and the electron-withdrawing trifluoromethyl group, which is crucial for modulating the physicochemical properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in areas like kinase inhibitors and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the CF₃ group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for functionalized ligands and monomers in the development of specialty polymers and advanced materials.
• Chemical Biology & Medicinal Chemistry: Employed as a core scaffold in fragment-based drug discovery and for creating chemical probes to study biological systems.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring the introduction of a fluorinated pyrazole moiety.

Basic Information

Product Name	4-(Trifluoromethyl)-1H-Pyrazole
CAS No.	52222-73-8
Molecular Formula	C₄H₃F₃N₂
Molecular Weight	136.08 g/mol
Synonyms	4-(Trifluoromethyl)pyrazole; 1H-Pyrazole, 4-(trifluoromethyl)-; 4-Trifluoromethylpyrazole; 4-(Trifluoromethyl)-1H-pyrazole; α,α,α-Trifluoro-1H-pyrazole-4-methanol (related); 4-CF3-Pyrazole; 4-Trifluoromethyl-1H-pyrazole
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)-1H-Pyrazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and industrial applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.