Description

3'-Iodo-5'-Methylacetophenone is a versatile iodinated aromatic ketone building block of significant importance in advanced organic synthesis. Its core value lies in providing a reactive iodine handle and a methyl-substituted acetophenone scaffold, enabling precise molecular construction for complex target molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for coupling reactions and functional group transformations.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers and liquid crystals.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Sonogashira couplings to form biaryl structures.
• Organic Synthesis Building Block: Utilized for further functionalization of the ketone group (e.g., reduction, oxidation, condensation) to create diverse chemical libraries.
• Chemical Research & Development: A valuable tool in academic and industrial R&D for exploring new synthetic methodologies and creating complex molecular architectures.

Basic Information

Item	Detail
Product Name	3'-Iodo-5'-Methylacetophenone
CAS No.	52107-81-0
Molecular Formula	C9H9IO
Molecular Weight	260.07 g/mol
Synonyms	1-(3-Iodo-5-methylphenyl)ethanone; 3'-Iodo-5'-methylacetophenone; 3-Iodo-5-methylacetophenone; 1-Acetyl-3-iodo-5-methylbenzene; 3-Iodo-5-methylphenyl methyl ketone; m-Iodo-m'-methylacetophenone; 3-Methyl-5-iodoacetophenone
EINECS	Contact for details

Quality Control

Our 3'-Iodo-5'-Methylacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing identity, assay, and impurity profiles to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.