Description

4-Hydroxy-3-Oxobutyl-1-Phosphonic Acid is a specialized organophosphorus compound that serves as a key intermediate in the synthesis of bisphosphonate drugs. Its unique structure, featuring both phosphonic acid and β-keto alcohol functionalities, makes it a versatile building block for creating molecules with high affinity for bone mineral. This compound is essential for manufacturers in the pharmaceutical sector requiring reliable, high-purity raw materials for complex API synthesis. Its role is critical in developing treatments for bone-related disorders, ensuring supply chain integrity and batch-to-batch consistency are paramount for our global B2B clients.

Application

• Pharmaceutical Intermediate: Primary use as a critical precursor in the synthesis of nitrogen-containing bisphosphonate active pharmaceutical ingredients (APIs) such as zoledronic acid and related compounds.
• Osteoporosis Treatment R&D: Serves as a key scaffold in research and development of novel bone resorption inhibitors for treating osteoporosis and Paget's disease.
• Bone-Targeting Molecule Synthesis: Utilized for constructing molecules designed to selectively bind to hydroxyapatite in bone tissue for targeted drug delivery systems.
• Chelating Agent Precursor: Acts as a starting material for synthesizing specialized chelating agents with applications in water treatment or metal sequestration.
• Chemical Research: Employed in academic and industrial laboratories for studying phosphonate chemistry and developing new organophosphorus compounds with biological activity.

Basic Information

Product Name	4-Hydroxy-3-Oxobutyl-1-Phosphonic Acid
CAS No.	51827-90-8
Molecular Formula	C4H9O6P
Molecular Weight	184.09 g/mol
Synonyms	1-Hydroxy-4-phosphonobutane-2-one; 4-Hydroxy-3-oxobutylphosphonic acid; 3-Oxo-4-hydroxybutyl-1-phosphonic Acid; 1-Hydroxy-2-keto-4-phosphonobutane; Zoledronic Acid Intermediate; (4-Hydroxy-3-oxobutyl)phosphonic acid; 4-Hydroxy-3-oxobutylphosphonate; HO-BP
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-3-Oxobutyl-1-Phosphonic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical intermediate applications. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring reliable supply and traceability for our global customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed after opening to minimize exposure to atmospheric moisture and light. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.