Description

3-4-Dehydro-L-Proline Methyl Ester is a high-value, non-proteinogenic proline derivative characterized by its unsaturated pyrrolidine ring. This compound serves as a versatile chiral building block and key intermediate in advanced organic synthesis. It is primarily utilized by research institutions and pharmaceutical companies for the development of novel peptide-based therapeutics, enzyme inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex drug candidates, particularly those targeting proteases and other enzymes.
• Peptidomimetics Research: Used to introduce conformational constraints and unsaturated bonds into peptide backbones for structure-activity relationship (SAR) studies.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes and labeled compounds for studying biological pathways.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material for the preparation of enantiomerically pure compounds.
• Agrochemical Research: Potential intermediate in the development of novel, biologically active compounds for crop protection.

Basic Information

Product Name	3-4-Dehydro-L-Proline Methyl Ester
CAS No.	51827-12-4
Molecular Formula	C6H9NO2
Molecular Weight	127.14 g/mol
Synonyms	Methyl (2S)-3,4-didehydroprolinate; Methyl L-3,4-dehydroprolinate; (S)-Methyl 3,4-didehydropyrrolidine-2-carboxylate; 3,4-Dehydro-L-proline methyl ester; δ3-L-Proline methyl ester; 1-Methyl 3,4-dehydroprolinate; (S)-Methyl 3-pyrroline-2-carboxylate
EINECS	Contact for details

Quality Control

Our 3-4-Dehydro-L-Proline Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.