Description

2',4',6'-Trifluoroacetophenone is a high-purity fluorinated aromatic ketone, a key building block in advanced organic synthesis. Its trifluoromethyl-substituted aromatic ring makes it a valuable intermediate for creating complex molecules with enhanced stability and bioavailability. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting the central nervous system and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the development of novel herbicides, pesticides, and fungicides, where the fluorine atoms improve metabolic stability and biological activity.
• Liquid Crystal & OLED Materials: Serves as a key raw material for synthesizing fluorinated compounds used in electronic displays and organic light-emitting diodes (OLEDs).
• Advanced Material Research: Employed in academic and industrial R&D for creating novel polymers, ligands for catalysis, and specialty fluorochemicals.
• Chemical Synthesis Building Block: Utilized in various organic reactions, including Grignard reactions, reductions, and nucleophilic additions, to introduce the trifluoroacetophenone moiety.

Basic Information

Product Name	2',4',6'-Trifluoroacetophenone
CAS No.	51788-77-3
Molecular Formula	C8H5F3O
Molecular Weight	174.12 g/mol
Synonyms	1-(2,4,6-Trifluorophenyl)ethanone; 2,4,6-Trifluoroacetophenone; α,α,α-Trifluoro-2,4,6-trihydroxyacetophenone (misnomer); 2,4,6-Trifluoro-1-acetylbenzene; Ethanone, 1-(2,4,6-trifluorophenyl)-; Trifluoroacetophenone (unspecified isomer); TFAP (abbreviation); 2,4,6-F3C6H2COCH3
EINECS	257-424-5

Quality Control

Our 2',4',6'-Trifluoroacetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, containers should be amber-colored or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.