Description

2-Aminoethyl 2-Hydroxypropyl Cellulose is a chemically modified cellulose ether derivative, engineered to introduce cationic aminoethyl groups onto a hydroxypropyl cellulose backbone. This modification is critical for enhancing bioadhesive properties and enabling controlled release in advanced pharmaceutical formulations. It serves as a key functional excipient for formulators in the pharmaceutical, biomedical, and personal care industries seeking to improve drug delivery efficacy and product performance.

Application

• Pharmaceutical Controlled Release Systems: As a matrix-forming agent for sustained and targeted drug delivery tablets, capsules, and patches.
• Ophthalmic & Nasal Formulations: Utilized in bioadhesive gels and solutions to prolong residence time and enhance drug absorption.
• Gene & Cell Therapy Vectors: Acts as a component in non-viral transfection systems and scaffolds for tissue engineering due to its cationic nature.
• Topical & Cosmetic Products: Functions as a film-forming, viscosity-modifying, and conditioning agent in creams, gels, and serums.
• Chromatography Media: Serves as a base material for the preparation of ion-exchange resins and affinity chromatography supports.
• Protein & Enzyme Immobilization: Provides a functionalized solid support for the covalent binding of biomolecules in diagnostic and biocatalytic applications.

Basic Information

Product Name	2-Aminoethyl 2-Hydroxypropyl Cellulose
CAS No.	51635-80-4
Molecular Formula	(C6H10O5)n with modifications
Molecular Weight	Variable (Polymer)
Synonyms	AE-HPC; Aminoethylhydroxypropyl Cellulose; 2-Hydroxypropyl Cellulose 2-Aminoethyl Ether; Cationic Hydroxypropyl Cellulose; HPC-AE; Cellulose, 2-hydroxypropyl ether, 2-aminoethyl ether; N-(2-Hydroxyethyl)aminomethyl hydroxypropyl cellulose
EINECS	Contact for details

Quality Control

Our 2-Aminoethyl 2-Hydroxypropyl Cellulose is manufactured under a cGMP-compliant quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and functional performance. Key parameters such as degree of substitution, nitrogen content, viscosity, and residual solvents are strictly controlled. Certificates of Analysis (COA) documenting full compliance with agreed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent moisture absorption and caking.

Specification

Item	Specification
Appearance	White to off-white powder or granules
Identification (IR)	Conforms to reference spectrum
Assay (Nitrogen Content)	1.5 - 3.5 % (or as per grade)
Degree of Substitution (Molar)	0.1 - 0.4 (or as per grade)
Viscosity (2% solution)	Specified range (e.g., 100-4000 mPa·s)
Loss on Drying	≤ 8.0 %
Residue on Ignition	≤ 1.0 %
pH (1% solution)	5.0 - 8.0
Heavy Metals	≤ 20 ppm
Microbial Limits	Meets Ph. Eur./USP criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.