Description

(2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-Hexaol is a high-purity stereoisomer of a six-carbon sugar alcohol, commonly known as D-Mannitol. This compound is a critical chiral building block and excipient valued for its non-hygroscopic nature (in its common form) and chemical stability, though this specific stereoisomer requires careful handling. Its primary value lies in providing precise stereochemical control and functionality in advanced synthesis and formulation. This product is essential for manufacturers in the pharmaceutical, biotechnology, food science, and specialty chemical sectors who require a reliable source of high-purity, well-characterized sugar alcohols for research, development, and production.

Application

• Pharmaceutical Excipient: Used as a non-reactive diluent, bulking agent, or tonicity agent in tablet formulations and lyophilized (freeze-dried) injectables.
• Chemical Synthesis Intermediate: Serves as a chiral starting material or precursor for the synthesis of more complex carbohydrates, nucleosides, and pharmaceutical active ingredients.
• Food & Beverage Industry: Employed as a low-calorie sweetener, texturizer, and anti-caking agent in sugar-free and dietetic products.
• Diagnostic Reagents: Used in the formulation of culture media, biochemical reagents, and testing kits within clinical and research laboratories.
• Cosmetics & Personal Care: Functions as a humectant and skin conditioning agent in creams, lotions, and toothpaste.
• Industrial Applications: Acts as a plasticizer in specialty resins, a dust control agent, and a component in explosives and pyrotechnics.

Basic Information

Item	Details
Product Name	(2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-Hexaol
CAS No.	133-43-7
Molecular Formula	C6H14O6
Molecular Weight	182.17 g/mol
Synonyms	D-Mannitol; Mannitol; Mannite; Cordycepic acid; Diosmol; Manicol; Osmiktrol; Osmofundin; Pearlitol; 1,2,3,4,5,6-Hexanehexol; (2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexaol
EINECS	205-788-7

Quality Control

Our (2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-Hexaol is produced and tested under a strict quality management system. Each batch is analyzed to ensure it meets stringent specifications for identity, purity, and stereochemical integrity. We can supply material compliant with various pharmacopeial standards, including USP-NF, Ph. Eur., JP, and FCC grades, depending on customer requirements. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure containers are kept tightly sealed to prevent absorption of atmospheric moisture, which can affect product quality and flow properties.

Specification

Item	Specification
Appearance	White crystalline powder or granules
Identification (IR)	Conforms to standard
Assay (HPLC)	≥ 98.0% (anhydrous basis)
Specific Rotation	[α]20/D: +23° to +25° (c=10 in H2O)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Reducing Sugars	Passes test
Bacterial Endotoxins*	< 0.5 EU/mg (for injectable grade)
Microbial Limits*	Conforms to USP <61>, <62> (for pharmaceutical grade)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.

* Applicable for relevant pharmaceutical grades.