Description

5-(Chloromethyl)-4-Methyl-1H-Imidazole Hydrochloride is a versatile and high-purity organic building block essential for advanced chemical synthesis. Its bifunctional structure, featuring both a reactive chloromethyl group and an imidazole core, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of histamine H3 receptor antagonists, antifungal agents, and other nitrogen-containing heterocyclic APIs.
• Agrochemical Synthesis: Building block for creating novel fungicides, herbicides, and plant growth regulators that leverage the imidazole moiety.
• Ligand and Catalyst Preparation: Used to synthesize specialized N-donor ligands for coordination chemistry and catalysis.
• Bioconjugation and Linker Chemistry: The reactive chloromethyl group enables its use in attaching payloads or creating chemical linkers in bioconjugate and prodrug development.
• Material Science Research: Intermediate for creating functionalized polymers, ionic liquids, or metal-organic frameworks (MOFs).
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthetic routes and scale-up projects.

Basic Information

Item	Details
Product Name	5-(Chloromethyl)-4-Methyl-1H-Imidazole Hydrochloride
CAS No.	51605-33-5
Molecular Formula	C5H8Cl2N2
Molecular Weight	167.04 g/mol
Synonyms	4-Methyl-5-(chloromethyl)-1H-imidazole hydrochloride; 5-(Chloromethyl)-4-methylimidazole hydrochloride; 4-Methyl-5-chloromethylimidazole hydrochloride; 1H-Imidazole, 5-(chloromethyl)-4-methyl-, hydrochloride (1:1); NSC 403914; 4-Methyl-5-imidazolemethyl chloride hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 5-(Chloromethyl)-4-Methyl-1H-Imidazole Hydrochloride is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the stringent requirements of our global clientele. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.