Description

4-Fluoro-5-(2,4,6-Trimethylphenyl)-1H-Pyrrole-2-Carboxylic Acid Methyl Ester is a high-value fluorinated pyrrole derivative, a key synthetic intermediate prized for its unique molecular architecture. Its core value lies in enabling the synthesis of complex molecules for advanced research and development, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for medicinal chemists and process development scientists working on novel active ingredients, where its specific substitution pattern is critical for modulating biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A crucial building block in the research and synthesis of novel drug candidates, particularly in the development of kinase inhibitors, anti-inflammatory agents, and other targeted therapies.
• Agrochemical Research: Serves as a key precursor in the development of new-generation pesticides and herbicides, where the fluorinated pyrrole core can contribute to enhanced efficacy and environmental profile.
• Material Science Precursor: Used in the synthesis of specialized organic materials, including ligands for catalysis or components for organic electronic applications.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.
• Academic & Institutional Research: Used in university and institutional laboratories for methodological development and exploration of new chemical spaces in heterocyclic chemistry.

Basic Information

Product Name	4-Fluoro-5-(2,4,6-Trimethylphenyl)-1H-Pyrrole-2-Carboxylic Acid Methyl Ester
CAS No.	51504-17-7
Molecular Formula	C15H16FNO2
Molecular Weight	261.29 g/mol
Synonyms	Methyl 4-fluoro-5-mesityl-1H-pyrrole-2-carboxylate; 4-Fluoro-5-mesityl-1H-pyrrole-2-carboxylic acid methyl ester; 1H-Pyrrole-2-carboxylic acid, 4-fluoro-5-(2,4,6-trimethylphenyl)-, methyl ester; Methyl 4-fluoro-5-(2,4,6-trimethylphenyl)-1H-pyrrole-2-carboxylate; 4-Fluoro-5-(2,4,6-trimethylphenyl)-1H-pyrrole-2-carboxylic acid methyl ester; 4-Fluoro-5-mesitylpyrrole-2-methyl carboxylate; CAS 51504-17-7
EINECS	Contact for details

Quality Control

Our production of 4-Fluoro-5-(2,4,6-Trimethylphenyl)-1H-Pyrrole-2-Carboxylic Acid Methyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, critical for sensitive R&D and scale-up processes. All materials are characterized using advanced analytical techniques including HPLC, GC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.