Description

4,5-Dihydro-5-Hydroxy-3-Methyl-5-(Trifluoromethyl)Isoxazole is a versatile heterocyclic building block characterized by its reactive isoxazoline ring and trifluoromethyl group. This compound matters for its role as a key synthetic intermediate in the development of advanced agrochemicals and pharmaceuticals, where the CF3 moiety is prized for enhancing metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the fine chemical, agrochemical, and pharmaceutical industries for constructing complex molecules.

Application

• Agrochemical Intermediate: A critical precursor in the synthesis of novel herbicides and fungicides, leveraging the trifluoromethyl group for improved bioactivity and environmental profile.
• Pharmaceutical Building Block: Used in medicinal chemistry for the construction of drug candidates, particularly where the isoxazoline scaffold and fluorine atoms are desired for target interaction and ADME properties.
• Fine Chemical Synthesis: Serves as a versatile reagent for introducing the 3-methyl-5-(trifluoromethyl)isoxazolidin-5-ol moiety into more complex organic architectures.
• Material Science Research: Potential intermediate for developing specialty polymers or functional materials with unique fluorinated properties.
• Cross-Coupling Reactions: The structure can be functionalized for use in palladium-catalyzed or other metal-mediated coupling reactions to create diverse chemical libraries.

Basic Information

Product Name	4,5-Dihydro-5-Hydroxy-3-Methyl-5-(Trifluoromethyl)Isoxazole
CAS No.	51479-84-6
Molecular Formula	C5H6F3NO2
Molecular Weight	169.10 g/mol
Synonyms	5-Hydroxy-3-methyl-5-(trifluoromethyl)-4,5-dihydroisoxazole; 3-Methyl-5-(trifluoromethyl)-5-hydroxy-4,5-dihydroisoxazole; 5-(Trifluoromethyl)-5-hydroxy-3-methyl-4,5-dihydroisoxazole; 4,5-Dihydro-5-hydroxy-3-methyl-5-(trifluoromethyl)-1,2-oxazole; Isoxazoline derivative 51479-84-6
EINECS	Contact for details

Quality Control

Our production of 4,5-Dihydro-5-Hydroxy-3-Methyl-5-(Trifluoromethyl)Isoxazole adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy for comprehensive characterization. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment, and our quality system supports compliance with cGMP and ISO standards for industrial and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong acids, bases, and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.