Description

(8R)-8-Hydroxyerythromycin is a key semi-synthetic derivative of the macrolide antibiotic erythromycin. This compound is of significant interest in pharmaceutical research and development due to its role as a crucial intermediate in synthesizing advanced antibiotic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers focused on developing novel antibacterial therapies and studying macrolide structure-activity relationships.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of next-generation macrolide antibiotics with improved efficacy and safety profiles.
• Antibacterial Research: Used in microbiological and pharmacological studies to investigate new mechanisms of action against resistant bacterial strains.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development and quality control in antibiotic production.
• Process Chemistry: Employed in scale-up and optimization studies for the industrial manufacturing of derivative antibiotic compounds.
• Medicinal Chemistry: A substrate for structural modification to create new chemical entities with potential therapeutic applications.

Basic Information

Product Name	(8R)-8-Hydroxyerythromycin
CAS No.	51433-36-4
Molecular Formula	C37H67NO14
Molecular Weight	749.93 g/mol
Synonyms	8(R)-Hydroxyerythromycin; Erythromycin, 8-hydroxy-, (8R)-; 8R-Hydroxyerythromycin A; 8-Hydroxyerythromycin (8R-isomer); NSC 330686; Erythromycin 8-hydroxide; 8R-HEM
EINECS	Contact for details

Quality Control

Our (8R)-8-Hydroxyerythromycin is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.