Description

(8S)-8-Hydroxyerythromycin is a semi-synthetic derivative of the macrolide antibiotic erythromycin, characterized by a hydroxyl group at the 8-position of the lactone ring. This structural modification is of significant interest for the development of novel antibiotics and as a key intermediate in pharmaceutical research, offering potential for enhanced activity or altered pharmacokinetic profiles. It is primarily utilized by research institutions and pharmaceutical companies engaged in antimicrobial development, chemical synthesis, and advanced pharmaceutical manufacturing.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced macrolide antibiotics and novel therapeutic agents.
• Antimicrobial Research: Used in biochemical and microbiological studies to investigate structure-activity relationships (SAR) and mechanisms of action against resistant bacterial strains.
• Chemical Reference Standard: Employed as a high-purity standard in analytical laboratories for quality control (QC) and method development using HPLC, LC-MS, or NMR.
• Process Chemistry: Acts as a starting material or intermediate in scale-up and optimization studies for Good Manufacturing Practice (GMP) production.
• Academic Research: Utilized in university and institutional labs for synthetic organic chemistry projects and pharmacological evaluations.

Basic Information

Product Name	(8S)-8-Hydroxyerythromycin
CAS No.	51433-35-3
Molecular Formula	C37H67NO14
Molecular Weight	749.93 g/mol
Synonyms	8(S)-Hydroxyerythromycin; Erythromycin, 8-hydroxy-, (8S)-; 8-Hydroxyerythromycin A; 8R*,9S*-Erythromycin 8,9-hemiacetal; 8-Hydroxyerythromycin (8S isomer); ABT 773 intermediate; Cethromycin intermediate; 8(S)-OH-Erythromycin
EINECS	Contact for details

Quality Control

Our (8S)-8-Hydroxyerythromycin is produced and tested under a rigorous quality management system. Each batch is characterized using advanced analytical techniques to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, impurities, and analytical methods (e.g., HPLC, NMR) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.