Description

2-Chloro-1-(3,4-Difluoro-Phenyl)-Ethanone is a high-purity, versatile organic intermediate featuring a reactive α-chloroketone group and a difluorinated aromatic ring. This molecular architecture makes it a critical building block for synthesizing more complex fluorinated compounds. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used to construct advanced fluorinated herbicides, fungicides, and pesticides, leveraging fluorine's ability to enhance bioavailability and metabolic stability.
• Liquid Crystal & OLED Material Research: Serves as a starting material for developing fluorinated aromatic cores used in electronic display and lighting technologies.
• Functional Polymer Monomer: Employed in the creation of specialty polymers with tailored properties like chemical resistance and thermal stability.
• Organic Synthesis Building Block: The reactive chloro and ketone groups allow for further functionalization, making it valuable for constructing complex molecular libraries in medicinal chemistry.

Basic Information

Product Name	2-Chloro-1-(3,4-Difluoro-Phenyl)-Ethanone
CAS No.	51336-95-9
Molecular Formula	C8H5ClF2O
Molecular Weight	190.57 g/mol
Synonyms	2-Chloro-1-(3,4-difluorophenyl)ethanone; 3',4'-Difluoro-2-chloroacetophenone; 2-Chloro-3',4'-difluoroacetophenone; 1-(3,4-Difluorophenyl)-2-chloroethanone; α-Chloro-3,4-difluoroacetophenone; 51336-95-9; Ethanone, 2-chloro-1-(3,4-difluorophenyl)-
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-1-(3,4-Difluoro-Phenyl)-Ethanone is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, and NMR is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.