Description

2-Chloro-3',4'-Difluoroacetophenone is a high-purity fluorinated aromatic ketone building block, essential for advanced organic synthesis. Its value lies in its precise molecular structure, which serves as a key intermediate for constructing complex molecules with specific electronic and steric properties. This compound is primarily needed by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of fluorinated drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystal compounds used in advanced display technologies.
• Organic Electronic Materials: Employed in the research and production of materials for organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Research & Development: A versatile reagent for exploring new fluorination reactions and constructing complex aromatic systems in academic and industrial labs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of tailored intermediates under cGMP conditions.

Basic Information

Product Name	2-Chloro-3',4'-Difluoroacetophenone
CAS No.	51336-95-6
Molecular Formula	C8H5ClF2O
Molecular Weight	190.57 g/mol
Synonyms	1-(2-Chloro-3,4-difluorophenyl)ethan-1-one; 2-Chloro-3,4-difluoroacetophenone; 3',4'-Difluoro-2-chloroacetophenone; 2-Chloro-3,4-difluoroacetophenone; α-Chloro-3,4-difluoroacetophenone; 1-Acetyl-2-chloro-3,4-difluorobenzene; Ethanone, 1-(2-chloro-3,4-difluorophenyl)-; 2-Chloro-3,4-difluorophenyl methyl ketone
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-3',4'-Difluoroacetophenone is manufactured and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency meet the stringent requirements of our global clientele. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.