Description

2-Chloro-2',4'-Difluoroacetophenone is a high-purity fluorinated aromatic ketone building block, essential for advanced organic synthesis. Its value lies in its unique halogenated structure, which serves as a versatile precursor for constructing complex molecules in pharmaceutical and agrochemical research. This compound is critically needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), liquid crystal materials, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those containing difluorophenyl motifs.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides where the chloro-difluoroacetophenone core provides specific biological activity.
• Liquid Crystal Materials: Serves as a building block for fluorine-containing liquid crystal compounds used in display technologies.
• Organic Light-Emitting Diodes (OLEDs): Employed in the research and production of fluorinated electron-transport materials.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions like Suzuki or Heck couplings for creating biaryl structures.
• Fine Chemical Research: Utilized in academic and industrial labs for method development and exploring new fluorination chemistry pathways.

Basic Information

Product Name	2-Chloro-2',4'-Difluoroacetophenone
CAS No.	51336-94-8
Molecular Formula	C8H5ClF2O
Molecular Weight	190.57 g/mol
Synonyms	1-(2,4-Difluorophenyl)-2-chloroethanone; 2-Chloro-1-(2,4-difluorophenyl)ethanone; 2',4'-Difluoro-2-chloroacetophenone; α-Chloro-2,4-difluoroacetophenone; 2-Chloro-2,4-difluoroacetophenone; 51336-94-8; Ethanone, 2-chloro-1-(2,4-difluorophenyl)-
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-2',4'-Difluoroacetophenone is produced under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency suitable for research and scale-up applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.