Description

2-Bromo-1,1-Difluorocyclopropane is a versatile and highly functionalized cyclopropane derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents on a strained three-membered ring, makes it a valuable precursor for introducing the difluorocyclopropyl moiety into target molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries who require sophisticated intermediates for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of bioactive molecules, particularly for introducing the metabolically stable difluorocyclopropyl group to modulate pharmacokinetic properties.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the difluorocyclopropane ring can enhance biological activity and environmental stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced materials with unique fluorinated properties.
• Organic Synthesis Building Block: Employed in cyclopropanation reactions, ring-opening transformations, and as a substrate for further functionalization via halogen exchange (e.g., Suzuki, Stille couplings).
• Ligand and Catalyst Development: Useful for creating novel fluorinated ligands for transition metal catalysis, impacting selectivity and reactivity in asymmetric synthesis.

Basic Information

Product Name	2-Bromo-1,1-Difluorocyclopropane
CAS No.	51326-64-8
Molecular Formula	C3H3BrF2
Molecular Weight	156.96 g/mol
Synonyms	1,1-Difluoro-2-bromocyclopropane; Bromodifluorocyclopropane; 2-Bromo-1,1-difluorocyclopropane; Cyclopropane, 2-bromo-1,1-difluoro-; 1-Bromo-2,2-difluorocyclopropane
EINECS	Contact for details

Quality Control

Our 2-Bromo-1,1-Difluorocyclopropane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (by GC or HPLC), identity confirmation (by IR, NMR), and impurity profiles. Our quality management system is designed to meet the stringent requirements of our global customer base in fine chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases. Recommended storage temperature is 2-8°C for extended stability. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.