Description

p-tert-Butyl-2,2,2-Trichloroacetophenone is a specialized organic intermediate featuring a reactive trichloromethyl ketone group adjacent to a tert-butyl-substituted aromatic ring. This unique structure makes it a valuable building block for synthesizing complex molecules, particularly in the development of advanced pharmaceuticals and high-performance agrochemicals. It is primarily sought by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of novel drug candidates, especially those requiring the introduction of the trichloromethyl ketone moiety or subsequent transformations into heterocycles.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the tert-butyl group can enhance biological activity and environmental stability.
• Organic Synthesis Building Block: Serves as a versatile precursor for various organic reactions, including nucleophilic substitutions, reductions, and cyclizations to create complex molecular architectures.
• Material Science Research: Investigated for the synthesis of specialized polymers, ligands, or photoinitiators where its specific steric and electronic properties are advantageous.
• Chemical Research & Development: Employed in academic and industrial labs for methodological studies and the development of new synthetic pathways.

Basic Information

Product Name	p-tert-Butyl-2,2,2-Trichloroacetophenone
CAS No.	51326-37-5
Molecular Formula	C12H13Cl3O
Molecular Weight	279.59 g/mol
Synonyms	1-[4-(1,1-Dimethylethyl)phenyl]-2,2,2-trichloroethanone; 4-tert-Butyl-2,2,2-trichloroacetophenone; 2,2,2-Trichloro-1-(4-tert-butylphenyl)ethanone; p-tert-Butyl-α,α,α-trichloroacetophenone; 4-(tert-Butyl)phenyl trichloromethyl ketone; Trichloro(4-tert-butylphenyl)methanone
EINECS	Contact for details

Quality Control

Our p-tert-Butyl-2,2,2-Trichloroacetophenone is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and IR/NMR for structural confirmation, to ensure it meets precise customer specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.