Description

α-Methyl-2-[3-(Trifluoromethyl)Phenyl]-5-Benzoxazoleacetic Acid is a high-value, non-steroidal anti-inflammatory drug (NSAID) intermediate with a distinct trifluoromethylated benzoxazole core structure. This compound matters for its critical role in the synthesis of advanced pharmaceutical agents, offering a unique pharmacophore that contributes to enhanced metabolic stability and receptor binding affinity. It is primarily needed by manufacturers in the pharmaceutical and fine chemical sectors engaged in the research and production of novel anti-inflammatory and analgesic medications.

Application

• Key Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of potent non-steroidal anti-inflammatory drugs (NSAIDs).
• Research & Development: Used in medicinal chemistry for the discovery and optimization of new therapeutic candidates targeting inflammation and pain.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses to introduce the benzoxazole-acetic acid moiety into complex molecules.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical manufacturing.
• Biochemical Research: Utilized in studies investigating cyclooxygenase (COX) enzyme inhibition mechanisms.

Basic Information

Product Name	α-Methyl-2-[3-(Trifluoromethyl)Phenyl]-5-Benzoxazoleacetic Acid
CAS No.	51234-70-9
Molecular Formula	C17H12F3NO3
Molecular Weight	335.28 g/mol
Synonyms	2-[3-(Trifluoromethyl)phenyl]-α-methyl-5-benzoxazoleacetic acid; 5-Benzoxazoleacetic acid, 2-[3-(trifluoromethyl)phenyl]-, α-methyl-; α-Methyl-2-(3-trifluoromethylphenyl)benzoxazole-5-acetic acid; L-745,337 (common research code); Trifluoromethylphenyl benzoxazole acetic acid derivative; 2-(3-Trifluoromethylphenyl)-α-methyl-1,3-benzoxazole-5-acetic acid; COX-2 inhibitor intermediate
EINECS	Contact for details

Quality Control

Our α-Methyl-2-[3-(Trifluoromethyl)Phenyl]-5-Benzoxazoleacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets the high standards required for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.