Description

N,o-Bis(Trimethylsilyl)-L-Tyrosine Trimethylsilyl Ester is a fully silylated derivative of the essential amino acid L-tyrosine, designed for advanced synthetic and analytical applications. This compound is a critical reagent for protecting sensitive functional groups, enabling complex peptide synthesis and derivatization processes in high-value research and development. It is primarily utilized by pharmaceutical R&D laboratories, analytical chemists, and fine chemical manufacturers for applications requiring precise molecular manipulation and analysis.

Application

• Gas Chromatography (GC) and Mass Spectrometry (MS) Derivatization: Enhances the volatility and thermal stability of L-tyrosine and related peptides for accurate analytical separation and detection.
• Peptide Synthesis Intermediate: Serves as a protected tyrosine building block in solid-phase and solution-phase peptide synthesis, preventing unwanted side reactions.
• Metabolite Analysis: Used in the preparation of biological samples for the quantification of tyrosine and its metabolites in pharmacokinetic and metabolomic studies.
• Reference Standard: Acts as a high-purity chemical standard for method development and validation in analytical laboratories.
• Organic Synthesis Reagent: Facilitates the introduction of the tyrosine moiety into complex organic molecules under mild, silyl-protecting conditions.
• Isotope-Labeled Compound Precursor: Used as a starting material for the synthesis of stable isotope-labeled (e.g., 13C, 15N) tyrosine derivatives for tracer studies.

Basic Information

Product Name	N,o-Bis(Trimethylsilyl)-L-Tyrosine Trimethylsilyl Ester
CAS No.	51220-73-6
Molecular Formula	C18H35NO3Si3
Molecular Weight	413.73 g/mol
Synonyms	L-Tyrosine, N,O-bis(trimethylsilyl)-, trimethylsilyl ester; Trimethylsilyl N,O-bis(trimethylsilyl)-L-tyrosinate; N,O-Bis(trimethylsilyl)-L-tyrosine TMS ester; TMS-Tyr(TMS)-OTMS; Fully silylated L-tyrosine; L-Tyrosine, N,O-bis(trimethylsilyl)-, trimethylsilyl ether; Tyrosine tris(trimethylsilyl) derivative
EINECS	Contact for details

Quality Control

Our N,o-Bis(Trimethylsilyl)-L-Tyrosine Trimethylsilyl Ester is manufactured under controlled conditions to ensure high chemical purity and batch-to-batch consistency. Each lot undergoes rigorous analytical testing, including HPLC, GC, and NMR, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.