Description

2-Isopropylmalonic Acid Dimethyl Ester is a high-purity diester derivative of malonic acid, serving as a versatile and critical building block in advanced organic synthesis. Its value lies in its role as a key precursor for introducing the isopropylmalonate moiety, enabling the construction of complex molecular architectures with specific steric and electronic properties. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring branched alkyl chains or specific carboxylic acid derivatives.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides where the isopropylmalonate structure contributes to biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Polymer & Material Science: Employed in the creation of novel monomers for specialty polymers, coatings, and resins with tailored properties.
• Fine Chemical & Flavor/Fragrance Intermediate: Utilized in the multi-step synthesis of complex aroma chemicals and other high-value fine chemicals.
• Academic & Industrial R&D: A valuable reagent for methodological development and exploring new synthetic pathways in organic chemistry laboratories.

Basic Information

Product Name	2-Isopropylmalonic Acid Dimethyl Ester
CAS No.	51122-91-9
Molecular Formula	C9H16O4
Molecular Weight	188.22 g/mol
Synonyms	Dimethyl 2-Isopropylmalonate; Dimethyl Isopropylmalonate; Isopropylmalonic Acid Dimethyl Ester; Propanedioic acid, 2-(1-methylethyl)-, 1,3-dimethyl ester; 2-(1-Methylethyl)propanedioic acid dimethyl ester; Dimethyl (2-isopropyl)malonate; 2-Isopropylpropanedioic acid dimethyl ester
EINECS	Contact for details

Quality Control

Our 2-Isopropylmalonic Acid Dimethyl Ester is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including chromatography (HPLC, GC) and spectroscopy (NMR, IR), to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider holding under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.