Description

1-Fluoro-5-Methylnaphthalene is a high-purity, fluorinated naphthalene derivative, serving as a versatile and critical building block in advanced organic synthesis. Its value lies in the strategic introduction of both fluorine and a methyl group onto the naphthalene scaffold, enabling precise modulation of electronic properties, lipophilicity, and metabolic stability in target molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries, where it is used to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and pesticides, where the fluorine atom enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a core structure or dopant in the production of advanced electronic display materials and organic light-emitting diodes (OLEDs).
• Ligand & Catalyst Development: Employed in organometallic chemistry to create specialized ligands for catalytic systems used in cross-coupling and other transformative reactions.
• Fluorescent Probe Synthesis: A precursor for developing naphthalene-based fluorescent dyes and molecular probes used in biochemical sensing and bioimaging.
• Polymer & Resin Modifier: Incorporated into polymer chains to alter physical properties such as thermal stability, refractive index, and chemical resistance.

Basic Information

Product Name	1-Fluoro-5-Methylnaphthalene
CAS No.	51010-55-0
Molecular Formula	C₁₁H₉F
Molecular Weight	160.19 g/mol
Synonyms	5-Methyl-1-fluoronaphthalene; 1-Fluoro-5-methylnaphthalene; 5-Methyl-1-fluoronaphthalene; 1-Fluoro-5-methyl-naphthalene; 51010-55-0; NSC 406902; 1-Fluoro-5-methyl-naphthalene; 5-Methyl-1-fluoronaphthalene
EINECS	Contact for details

Quality Control

Every batch of 1-Fluoro-5-Methylnaphthalene is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. Our standard grade typically meets a purity specification of ≥97% (by GC or HPLC), with detailed impurity profiling available. A comprehensive Certificate of Analysis (COA) is provided with each shipment, documenting identity, assay, and purity results. We support custom synthesis and can tailor specifications to meet specific project requirements, including adherence to cGMP standards for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.