Description

(5Z,9S,11R,13E,15S)-9,11,15-Tris[(Trimethylsilyl)Oxy]Prosta-5,13-Dien-1-Oic Acid Trimethylsilyl Ester is a key protected intermediate in the synthesis of prostaglandins and their analogs. This compound is critical for pharmaceutical research and development, offering a stable, silylated form for complex organic transformations. It is primarily utilized by researchers and manufacturers in the pharmaceutical and fine chemical industries for the production of advanced therapeutic agents.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of prostaglandin-based drugs, including those targeting ocular hypertension (glaucoma), gastric ulcers, and cardiovascular conditions.
• Organic Synthesis: Used in advanced multi-step syntheses to introduce the prostaglandin skeleton or specific functional groups under protective conditions.
• Biochemical Research: Serves as a standard or precursor in studies investigating the biological activity and metabolic pathways of eicosanoids.
• Process Development: Employed in scaling up and optimizing manufacturing routes for prostaglandin APIs (Active Pharmaceutical Ingredients).
• Reference Standard: Can be utilized as a high-purity analytical reference material for quality control in pharmaceutical production.

Basic Information

Product Name	(5Z,9S,11R,13E,15S)-9,11,15-Tris[(Trimethylsilyl)Oxy]Prosta-5,13-Dien-1-Oic Acid Trimethylsilyl Ester
CAS No.	50669-95-9
Molecular Formula	C₃₀H₅₈O₅Si₄
Molecular Weight	615.15 g/mol
Synonyms	Prostaglandin F2α Trimethylsilyl Ester; PGF2α-TMS; 9,11,15-Tris-O-TMS Prostaglandin F2α TMS Ester; (5Z,9α,11α,13E,15S)-9,11,15-Tris(trimethylsilyloxy)prosta-5,13-dien-1-oic Acid Trimethylsilyl Ester; TMS Derivative of PGF2α; Prosta-5,13-dien-1-oic Acid, 9,11,15-tris[(trimethylsilyl)oxy]-, Trimethylsilyl Ester, (5Z,9S,11R,13E,15S)-
EINECS	Contact for details

Quality Control

Our (5Z,9S,11R,13E,15S)-9,11,15-Tris[(Trimethylsilyl)Oxy]Prosta-5,13-Dien-1-Oic Acid Trimethylsilyl Ester is produced and handled under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its moisture-sensitive and light-sensitive nature. Allow the container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous oil or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay	≥ 90% (by NMR or titration)
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.